肖卫华

导师介绍

姓名

肖卫华


 

工作单位

中国科学技术大学先进技术研究院/中国科学技术大学生命科学院

学位/职称

博士/教授

办公室电话

0551-63606294

Email

xiaow@ustc.edu.cn

教育背景

1980-1985 白求恩医科大学 临床医学本科

1998-2002 美国霍普金斯大学 生物信息学硕士

2005-2012 吉林大学 内科学博士

研究方向

1. 肿瘤免疫;

2. 生物技术药物

任职经历

1985-1995 长春生物制品研究所应用分子生物学 助研

1995-1998 美国马里兰大学肿瘤研究中心 博士后

1998-2004 美国国立卫生研究院肿瘤研究所(NIH, NCI) 研究员

2004-现在 中国科学技术大学生命科学院 教授

获得荣誉、奖项

第四届中国创新创业大赛医药团队组第三名。

主持、参与项目

1. NK免疫细胞制品产业开发及临床新技术应用实验研究,安徽省重大研究项目,主持;

2. 逆转免疫耗竭的新机制新策略,中科院先导专项B, 自课题负责;

3. 逆转免疫抑制为机制的肿瘤免疫治疗产品研发,科技部重大专项,子课题负责

论文、著作

1: Sun H, Sun C, Xiao W, Sun R. Tissue-resident lymphocytes: from adaptive to innate immunity. Cell Mol Immunol. 2019 Jan 11.

2: Sun H, Huang Q, Huang M, Wen H, Lin R, Zheng M, Qu K, Li K, Wei H, Xiao W, Sun R, Tian Z, Sun C. Human CD96 correlates to NK cell exhaustion and predicts the prognosis of human hepatocellular carcinoma. Hepatology. 2018 Nov 8. doi: 10.1002/hep.30347.

3: Sun H, Xu J, Huang Q, Huang M, Li K, Qu K, Wen H, Lin R, Zheng M, Wei H, Xiao W, Sun R, Tian Z, Sun C. Reduced CD160 Expression Contributes to Impaired NK-cell Function and Poor Clinical Outcomes in Patients with HCC. Cancer Res. 2018 Dec 1;78(23):6581-6593.

4: Fang F, Xiao W, Tian Z. Challenges of NK cell-based immunotherapy in the new era. Front Med. 2018 Aug;12(4):440-450.

5: Fang F, Xiao W, Tian Z. NK cell-based immunotherapy for cancer. Semin Immunol.

2017 Jun;31:37-54. doi: 10.1016/j.smim.2017.07.009. Epub 2017 Aug 31. Review. PubMed PMID: 28838796.

6: Qian L, Xu F, Wang X, Jiang M, Wang J, Song W, Wu D, Shen Z, Feng D, Ling B, Cheng Y, Xiao W, Shan G, Zhou Y. LncRNA expression profile of ΔNp63α in cervical squamous cancers and its suppressive effects on LIF expression. Cytokine. 2017 Aug;96:114-122.

7: Li R, Fang F, Jiang M, Wang C, Ma J, Kang W, Zhang Q, Miao Y, Wang D, Guo Y, Zhang L, Guo Y, Zhao H, Yang, Tian Z, Xiao W. STAT3 and NF-κB are Simultaneously Suppressed in Dendritic Cells in Lung Cancer. Sci Rep. 2017 Mar 28;7:45395.

8: Sun C, Xu J, Huang Q, Huang M, Wen H, Zhang C, Wang J, Song J, Zheng M, Sun H, Wei H, Xiao W, Sun R, Tian Z. High NKG2A expression contributes to NK cell exhaustion and predicts a poor prognosis of patients with liver cancer. Oncoimmunology. 2016 Dec 7;6(1):e1264562.

9: Jia H, Guo Y, Song X, Shao C, Wu J, Ma J, Shi M, Miao Y, Li R, Wang D, Tian Z, Xiao W. Elimination of N-glycosylation by site mutation further prolongs the half-life of IFN-α/Fc fusion proteins expressed in Pichia pastoris. Microb Cell Fact. 2016 Dec 7;15(1):209.

10: Sun H, Song J, Weng C, Xu J, Huang M, Huang Q, Sun R, Xiao W, Sun C.

Association of decreased expression of the macrophage scavenger receptor MARCO with tumor progression and poor prognosis in human hepatocellular carcinoma. J Gastroenterol Hepatol. 2017 May;32(5):1107-1114.