孙宝林

导师介绍

姓名

孙宝林


工作单位

中国科学技术大学先进技术研究院/中国科学技术大学生命科学学院

学位/职称

博士/教授

办公室电话

0551-63606748

Email

sunb@ustc.edu.cn

教育背景

美国Michigan State University微生物学博士

研究方向

细菌病原体的耐药与致病性发生的分子机制研究

任职经历

2004年至今,中国科学技术大大学生命科学学院,教授。

获得荣誉、奖项

1. 王宽诚育才奖(一等奖)(2008)

2. 研究生导师招生先锋奖(2011)

 

主持、参与项目

1. 结核病靶标研究(2008年科技部重大传染病防治专项)

2. 金黄色葡萄球菌临床菌株III-A CRISPR-Cas 系统的功能与机制研究(2017年面上项目)

3. 金黄色葡萄球菌群体感应信号分子AI-2的受体鉴定及调控致病性的分子机制(2019年面上项目)

4. 金黄色葡萄球菌耐药发生的分子机制研究(2019中科院先导专项)

论文、著作

1. Jiang Q, Jin Z, Sun B (2018). MgrA negatively regulates biofilm formation and detachment by repressing the expression of psm operons in Staphylococcus aureus. Appl Environ Microbiol 84:e01008-18.

2. Wen W, Liu B, Xue L, Zhu Z, Niu L, Sun B (2018). Autoregulation and virulence control by the toxin-antitoxin system SavRS in Staphylococcus aureus. Infect Immun 86:e00032-18.

3. Guan J, Wang W, Sun B (2017). Chromosomal targeting by the type III-A CRISPR-Cas system can reshape genomes in Staphylococcus aureus. mSphere 2:e00403-17.

4. Zhao C, Shu X, Sun B (2017). Construction of a gene knockdown system based on catalytically inactive ("dead") Cas9 (dCas9) in Staphylococcus aureus. Appl Environ Microbiol 83:e00291-17.

5. Liu X, Zhang S, Sun B (2016). SpoVG regulates cell wall metabolism and oxacillin resistance in methicillin-resistant Staphylococcus aureus strain N315. Antimicrob Agents Chemother 60:3455–3461.

6. Zhang S, Ma R, Liu X, Zhang X, Sun B (2015). Modulation of ccrAB expression and SCCmec excision by an inverted repeat element and SarS in methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 59:6223-6232.

7. Chen C, Zhang X, Shang F, Sun H, Sun B, Xue T (2015). The Staphylococcus aureus protein-coding gene gdpS modulates sarS expression via mRNA-mRNA interaction. Infect Immun 83:3302-3310.

8. Hu J, Zhang X, Liu X, Chen C, Sun B (2015). Mechanism of reduced vancomycin susceptibility conferred by walK mutation in community-acquired methicillin-resistant Staphylococcus aureus strain MW2. Antimicrob Agents Chemother 59:1352-1355.

9. Xue T, You Y, Hong D, Sun H, Sun B (2011). The Staphylococcus aureus KdpDE two-component system couples extracellular K+ sensing and Agr signaling to infection programming. Infect Immun 79:2154-2167.

10. Zhao L, Xue T, Shang F, Sun H, Sun B (2010). Staphylococcus aureus AI-2 quorum sensing associates with the KdpDE two-component system to regulate capsular polysaccharide synthesis and virulence. Infect Immun 78:3506-3515.

11. Tao L, Wu X, Sun B (2010). Alternative sigma factor σH modulates prophage integration and excision in Staphylococcus aureus. PLoS Pathog 6:e1000888.

12. Shang F, Xue T, Sun H, Xing L, Zhang S, Yang Z, Zhang L, Sun B (2009). The Staphylococcus aureus GGDEF domain-containing protein, GdpS, influences protein A gene expression in a cyclic diguanylic acid-independent manner. Infect Immun 77:2849-2856.