刘丹

导师介绍

姓名

刘丹


 

工作单位

中国科学技术大学先进技术研究院/中国科学技术大学生命科学学院

学位/职称

教授

办公室电话

0551 63601619

Email

dliu919@ustc.edu.cn

教育背景

2001/09-2007/06, 中国科学技术大学,生命科学学院,博士,导师:姚雪彪教授

1997/09-2001/06,中国科学技术大学,生命科学学院,本科生

研究方向

细胞有丝分裂及蛋白质翻译后修饰

任职经历

2013-     中国科学技术大学生命科学院,细胞生物学系,教授,中组部青年千人。

2007-2013 宾夕法尼亚大学生物系,博士后,指导教授Michael Lampson。

2005-2006 京都大学生物物理系访问学者,指导教授Kunio Takeyasu。

获得荣誉、奖项


主持、参与项目

1 国家重大研究计划项目:组织干细胞异常与CSC形成中的乙酰化修饰水平及关键调控因子研究 (项目编号:2016YFA0101200,2016.7-2020.12,183.75万元),在研中;

2 国家973计划项目:炎-癌生物信号交互调控癌进展及阻抑治疗分子机制 (项目编号:2015CB553701,2015.1-2019.12,100万元),在研中;

3 重大研究计划培育项目:组蛋白修饰调控Aβ诱导Tau蛋白表达及过度磷酸化的过程研究 (项目编号:91749125,2018.1-2020.12,60万元),在研中;

4 国家自然科学基金面上项目:CD147 N-糖基化的FRET检测方法学的建立及其抑制剂的发现研究 (项目编号:21778050,2018.1-2021.12,64万元), 在研中;

5 国家重大新药创制项目:国家一类化学新药紫杉肽临床研究 (项目编号:2015ZX09101002,2015.1-2018.12,716.83万元),已结题;

6 13年青年千人计划:有丝分裂激酶PLK1底物筛选及机制研究 (项目编号:KJ2070000027,2013.03-2017.03,300万元),已结题;

7 中国科学技术大学青年创新基金:有丝分裂激酶调控机制的研究 (项目编号:WK2070000037,2013.12-2015.12,20万元),已结题。

论文、著作

Wan J., Duan W,. Chen K., Tao Y., Dang J., Zeng K., Ge Y.*, Wu J.*, Liu D.*. Selective and sensitive detection of Zn (II) ion using a simple peptide-based sensor. Sensor Actuat B-Chem 2018, 255: 49-56.

Yang JC, Rong H, Shao P, Tao Y, Dang J, Wang P, Ge YS, Wu J, Liu D *. Highly Selective Ratiometric Peptide-based Chemosensors for Zinc Ion and Application in Living Cell Image: A Study for Reasonable Structure Designing. J. Mat.Chem B, 2016, 4, 6065-6073.

Liu Y, Duan W, Song W, Liu J J, Ren C, Wu J, Liu D, Chen H L. Red Emission B, N, S-co-Doped Carbon Dots for Colorimetric and Fluorescent Dual Mode Detection of Fe3+ Ions in Complex Biological Fluids and Living Cells[J]. ACS Applied Materials & Interfaces, 2017, 9(14): 12663-12672.

Yu F, Jiang Y, Lu L, Cao M, Qiao Y, Liu X, Liu D, Dyke T, Wang F W, Yao X, Guo J, Yang Z. Aurora-A promotes the establishment of spindle assembly checkpoint by priming the Haspin-Aurora-B feedback loop in late G2 phase[J]. Cell discovery, 2017, 3: 16049.

Liu D., Davydenko O., Lampson M.A. Polo-like kinase-1 regulates kinetochore-microtubule dynamics and spindle checkpoint silencing. J Cell Biol. 2012 Aug; 198:491-499. 引用次数: 51

Welburn J.P., Vleugel M., Liu D., Yates III J.R., Lampson M.A., Fukagawa T., Cheeseman I.M. Aurora B Phosphorylates Spatially Distinct Targets to Differentially Regulate the Kinetochore-Microtubule Interface. Mol. Cell. 2010 May; 38:383-392. 引用次数: 231

Liu D., Vleugel M., Backer C.B., Hori T., Fukagawa T., Cheeseman I.M., Lampson M.A. Regulated targeting of protein phosphatase 1 to the outer kinetochore by KNL1 opposes Aurora B kinase. J Cell Biol. 2010 March; 188:809-820. 引用次数: 174

Liu D., Vader G., Vromans M.J., Lampson M.A., Lens S.M. Sensing chromosome bi-orientation by spatial separation of aurora B kinase from kinetochore substrates. Science. 2009 Mar; 323:1350-1353. 引用次数: 320

Liu D., Ding X., Du J., Cai X., Huang Y., Ward T., Shaw A., Yang Y., Hu R., Jin C., Yao X. Human NUF2 interacts with centromere-associated protein E and is essential for a stable spindle microtubule-kinetochore attachment. J Biol Chem. 2007 July; 282:21415-21424. 引用次数: 51

Liu D.†, Ge L.†, Wang F., Takahashi H., Wang D., Guo Z., Yoshimura S.H., Ward T., Ding X., Takeyasu K., Yao X. Single-molecule detection of phosphorylation-induced plasticity changes during ezrin activation.  FEBS Lett. 2007 Jul; 581:3563-3571. († equal contribution)  引用次数: 18

Liu D., Zhang N., Du J., Cai X., Zhu M., Jin C., Dou Z., Feng C., Yang Y., Liu L., Takeyasu K., Xie W., Yao X. 2006. Interaction of Skp1 with CENP-E at the midbody is essential for cytokinesis. Biochem Biophys Res Commun. 2006 Apr; 345:394-402.  引用次数: 24

Xue Y.†, Liu D.†, Fu C., Dou Z., Zhou Q., Yao X. A novel genome-wide full-length kinesin prediction analysis reveals additional mammalian kinesins. Chinese Science Bulletin. 2006 Aug; 51:1836-1847. († equal contribution)  引用次数: 5

 

综述:

 

Liu D., Lampson M.A. Regulation of kinetochore-microtubule attachments by Aurora B kinase. Biochem Soc Trans. 2009 Oct; 37(5):976-980. 引用次数: 39

 

Liu D., Jin C., Yao X. Progress and perspective of the kinetochore-associated motor proteins. Chinese Science Bulletin. 2003 Jan; 48(2):111-117.