工作单位

中国科学技术大学先进技术研究院/中国科学技术大学生命科学学院

学位/职称

博士/教授

办公室电话

0551-63601736

Email

wxiong@ustc.edu.cn

教育背景

2001年毕业于北京大学生命科学学院，获理学学士学位

2006年毕业于北京大学生命科学学院，获理学博士学位

2006至2013年，在美国国立卫生研究院（NIH）酒精滥用与酒精中毒研究所（NIAAA）做博士后研究工作

研究方向

1. 离子通道受体的调节机制及相关小分子药物的设计与合成

2. 质谱技术在神经科学中的应用

3. 情绪认知调节感知觉的神经环路机制

4. 神经退行性疾病的发病机制

任职经历

2006至2013年，在美国国立卫生研究院（NIH）酒精滥用与酒精中毒研究所（NIAAA）做博士后研究工作

2013年至今，中国科学技术大学生命科学学院, 中科院脑科学与智能技术卓越创新中心骨干成员，教授博导

主持、参与项目

个人获奖

文章被美国药物依赖研究所（NIDA）评选为“FEATURED PAPER OF THE MONTH”。曾获得2011年度美国国立卫生研究院颁发给优秀研究人员的奖项“Fellows Award for Research Excellence”。

代表性论著

1.Hongying Zhu#; Ning Wang#; Lei Yao; Qi Chen; Ran Zhang; Junchao Qian; Yiwen Hou; Weiwei Guo; Sijia Fan; Siling Liu; Qiaoyun Zhao; Feng Du; Xin Zuo; Yujun Guo; Yan Xu; Jiali Li; Tian Xue; Kai Zhong; Xiaoyuan Song; Guangming Huang*;Wei Xiong*. Moderate UV exposure enhances learning and memory by promoting a novel glutamate biosynthetic pathway in the brain.Cell,https://doi.org/10.1016/j.cell.2018.04.014. (2018)

2. Hongying Zhu#, Guichang Zou#, Ning Wang#, Meihui Zhuang,Wei Xiong* & Guangming Huang*. Single-neuron identification of chemical constituents, physiological changes, and metabolism using mass spectrometry.PNAS, 114: 2586~2591 (2017)

3. Jieping Lu#; Sijia Fan#; Guichang Zou; Yiwen Hou; Tao Pan; Weiwei Guo; Lei Yao; Feng Du; GE Homanics; Dan Liu; Li Zhang;Wei Xiong*. Involvement of glycine receptor α1 subunits in cannabinoid-induced analgesia.Neuropharmacology, 133: 224~232 (2018)

4.Wei Xiong, Shao-Rui Chen, Liming He, Kejun Cheng, Yi-Lin Zhao, Hong Chen, De-Pei Li, Gregg E. Homanics, John Peever, Kenner C. Rice, Ling-gang Wu, Hui-Lin Pan & Li Zhang. Presynaptic glycine receptors as a potential therapeutic target for hyperekplexia disease. Nature Neuroscience, 17: 232-239 (2014)

5.Wei Xiong, KeJun Chen, Tanxing Cui, Grzegorz Godlewski, Kenner Rice, Yan Xu and Li Zhang. Cannabinoid potentiation of glycine receptors contributes to cannabis-induced analgesia. Nature Chemical Biology,7: 296-303(2011)

6.Wei Xiong, Tanxing Cui, Kejun Cheng, Fei Yang, Shao-Rui Chen, Dan Willenbring, Yun Guan, Hui-Lin Pan, Ke Ren, Yan Xu and Li Zhang. Cannabinoids suppress inflammatory and neuropathic pain by targetingα3 glycine receptors. Journal of Experimental Medicine, 209 (6): 1121-1134 (2012)

7.Wei Xiong, Xiongwu Wu, David M. Lovinger and Li Zhang. A Common Molecular Basis for Exogenous and Endogenous Cannabinoid Potentiation of Glycine Receptors. Journal of Neuroscience, 32 (15): 5200-5208 (2012)

8.Zhifeng Zhou, Camilla Karlsson, Tiebing Liang, Wei Xiong, Mitsuru Kimura, Jenica D. Tapocik, Qiaoping Yuan, Estelle Barbier, Austin Feng, Meghan Flanigan, Eric Augier, Mary-Anne Enoch, Colin A. Hodgkinson, Pei-Hong Shen, David M. Lovinger, Howard J. Edenberg, Markus Heilig, and David Goldman. Loss of metabotropic glutamate receptor 2 escalates alcohol consumption. PNAS, 110(42):16963-8 (2013)

9.Wei Xiong, Masako Hosoi, Bon-Nyeo Koo, and Li Zhang. Anandamide Inhibition of 5-HT3A Receptors Varies with Receptor Density and Desensitization. Molecular Pharmacology, 73:314-322 (2008)

10.Wei Xiong*,Bon-Nyeo Koo, Russell Morton and Li Zhang. Psychotropic andnonpsychotropic cannabis derivatives inhibit human 5-HT3A receptors through a receptor desensitization-dependent mechanism. Neuroscience,184: 28-37(2011) *Corresponding Author

11.Yan Zhang, Wei Xiong, Xiaojin Lin, Xiang Ma and Long-Chuan Yu. Receptor trafficking induced by mu-opioid-receptor phosphorylation. Neuroscience & Biobehavioral Reviews, 33: 1192-1197 (2009)

12.Cecilia M. Borghese, Wei Xiong, S. Irene Oh, Angel Ho, John Mihic, Li Zhang, David M. Lovinger and Gregg E. Homanics. Mutations M287L and Q266I in the glycine receptor alpha1 subunit change sensitivity to volatile anesthetics in oocytes and neurons, but Not the minimal alveolar concentration in Knockin Mice. Anesthesiology,117(4):765-71 (2012)

13.Cecilia M. Borghese,Yuri A. Blednov, Yu Quan, Sangeetha V. Iyer, Wei Xiong, S. John Mihic, Li Zhang, David M. Lovinger, James R. Trudell, Gregg E. Homanics, R. Adron Harris. Characterization of Two Mutations, M287L and Q266I, in theα1 Glycine Receptor Subunit That Modify Sensitivity to Alcohols. Journal of Pharmacology and Experimental Therapeutics, 340: 304-316 (2012)