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校内导师

徐允河

文章来源:本站原创

发布时间:2021-05-23 14:21:38

文章作者:本站编辑

导师介绍

姓名

徐允河

性别

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职称/职务

特任教授

出生年月

1980.7

最高学历

研究生

固定电话

18256049969

工作单位

化学与材料科学学院

联系地址

安徽省合肥市包河区中国科学技术大学化学与材料科学学院

邮箱

xyh0709@ustc.edu.cn

教育背景

1999.9-2003.7 青岛大学,本科,化学专业

2003.9-2006.1 南开大学,硕士,无机化学专业

2006.9-2010.9 新加坡南洋理工大学,博士,有机化学专业

2010.10-2012.2新加坡南洋理工大学,博士后,有机化学专业

研究方向

 

1)有机硅合成及应用研究。

2)新型有机金属有机试剂制备、合成及应用研究。

3)药物活性分子和天然产物有机分子的合成研究

任职经历

 

2012.2-2020.10 中国科学技术大学 化学与材料科学学院 副教授

2020.11-至今   中国科学技术大学 化学与材料科学学院 特任教授

主持、参与

项目

1) “铜催化的Si-B 键活化以及C-Si 键生成反应的研究” 2013-2015 年,基金委, 国家自然基金青年面上项目, 25 万,项目主持人,21202156

2) “钯催化的烯烃烷基化反应” 2013-2015 年,安徽省市地方,安徽省青年面上项目,5万,项目主持人,1308085QB37

3) “钯催化的羰基化合物α-位烯基化反应的研究” 2013-2015 年, 教育部,新教师基金项目,4 万,项目主持人,20123402120019

4) “过渡金属催化的烯烃C-H 键官能化反应制备杂环化合物的研究” 2013-2015 年,教育部,中科大青年创新基金项目,20 万,项目主持人,WK2060190023

5)“钯催化的烯烃C-H 键活化以及烷基化反应”2013-2014 年,教育部,博士后面上基金项目,5 万,项目主持人,BH2060190036

6) “过渡金属催化的烯烃C-H键活化和官能化反应的研究及在天然产物合成中的应用”

2014-2017年, 基金委,国家自然基金面上项目,85万,项目主要参与人,21372210

7)“铜催化不饱和碳-碳键硅基化反应的研究” 2017-2020年, 基金委,国家自然基金面上项目,65万(直接费用),项目主持人,21672198

8) “富电子烯烃Heck反应引发串联偶联反应制备含氮化合物的研究” 2017-2019 年,安徽省市地方,安徽省面上项目,8万,项目主持人,BJ2060190070

9)“铜催化可控性多途径碳-硅键生成反应的研究”,2016-2017年,南开大学元素有机化学国家重点实验室,3万,项目主持人,201620

10)“铜催化共轭不饱和键不对称硅基化反应的研究”,2017-2018年,杭州师范大学有机硅化学及材料技术教育部重点实验室,10万,项目主持人,2017001。

11)  “药物和有机功能材料导向的精准硅/硼化反应研究”,2017-2019年,校创新团队培育基金,100万,项目主要参与人。

12)“过渡金属催化有机硅、硼产物合成及其在药物合成中的应用研究”,2017-2019年,中国科学技术大学引进人才启动经费,50万, 项目主持人。

13)“过渡金属催化联烯丙基硼试剂制备和应用的研究” 2019-2022,基金委面上项目,84万,项目主持人,21871240。

14)“铜催化功能性有机硼试剂合成与应用的研究”2020-2021,南开大学元素有机化学国家重点实验室,3万,项目主持人,201907

15)“中国科大-万方精细化学品联合实验室课题4”2020-2021,企业联合实验室,80万,项目主持人, KD200328(合同号),EF2060190004(指标卡号)

16) “铜催化硅烷与不饱和C-C键硅氢化反应的研究” 2021-2024,南开大学元素有机化学国家重点实验室,9万,项目主持人,202001

17)“药物和有机功能材料导向的精准硅/硼化反应研究”,2020-2023年,校创新团队滚动支持基金,100万,项目主要参与人。

18) 青年长江配套研究经费, 100万, 微尺度国家研究中心,项目主持人,SA2340000009(指标卡号)

荣誉、奖项

1) “Thieme Chemistry Journals Award” 2017

2)2015年中国科学技术大学“张宗植青年教师奖”

3)2020年教育部“青年长江学者”

 

科研成果

1)     Catalytic Asymmetric Conjugate Protosilylation and Protoborylation of 2‑Trifluoromethyl Enynes for Synthesis of Functionalized Allenes

Chao Yang, Zheng-Li Liu, Dong-Ting Dai, Qi Li, Wei-Wei Ma, Meng Zhao, Yun-He Xu

Org. Lett. 2020, 22, 1360-1367.

2)     Synthesis of Functionalized Vinylsilanes via Metal-Free Dehydrogenative Silylation of Enamides

Xi-Hao Chang, Zi-Lu Wang, Meng Zhao, Chao Yang, Jie-Jun Li, Wei-Wei Ma, Yun-He Xu

Org. Lett. 2020, 22, 1326-1330.

3)     Palladium(II)-Catalyzed Stereospecific Alkenyl C–H Bond Alkylation of Allylamines with Alkyl Iodides

Yun-Cheng Luo, Chao Yang, Sheng-Qi Qiu, Qiu-Ju Liang, Yun-He Xu*, Teck-Peng Loh*

ACS Catal. 2019, 9, 4271-4276.

4)     Divergent Protosilylation and Protoborylation of Polar Enynes

Fei-Fan Meng, Qi-Yan Xue, Bing Jiang, Meng Zhao, Jia-Hao Xie, Yun-He Xu*, Teck-Peng Loh

Org. Lett. 2019, 21, 2932-2936.

5)     Palladium-Catalyzed Cycloaromatization/Alkylation of o-(Alkynyl)styrenes

    Shu-Sen Li, Meng Zhao, Xiao-Wei Liu, Jian-Lin Xu, Yun-He Xu,* Teck-Peng Loh*

    J. Org. Chem. 2019, 84, 12848-12855.

4)     Palladium-Catalyzed Dialkylation of C–C Triple Bonds: Access to Multi-Functionalized Indenes

Xiao-Wei Liu, Shu-Sen Li, Dong-Ting Dai, Meng Zhao, Cui-Cui Shan, Yun-He Xu*, Teck-Peng Loh*

Org. Lett. 2019, 21, 3696-3700.

5)     Palladium-Catalyzed Cascade Intramolecular Cyclization and Allylation of Enynoates with Allylic Alcohols

Sheng-Qi Qiu, Tanveer Ahmad, Yun-He Xu*, Teck-Peng Loh*

J. Org. Chem. 2019, 84, 6729-6736.

6)     Copper-catalyzed regiodivergent 1,4- and 1,6-conjugate silyl addition to diendioates: access to functionalized allylsilanes

Tanveer Ahmad, Qi Li,Sheng-Qi Qiu, Jian-Lin Xu, Yun-He Xu*, Teck-Peng Loh

Org. Biomol. Chem. 2019, 17, 6122–6126.

7)     Copper-Catalyzed Asymmetric Silylation of Propargyl Dichlorides: Access to Enantioenriched Functionalized Allenylsilanes

Zheng-Li Liu, Chao Yang, Qi-Yan Xue, Meng Zhao, Cui-Cui Shan, Yun-He Xu*, Teck-Peng Loh

Angew.Chem. Int.Ed. 2019, 58, 16538–16542.

8)     Macrolide Synthesis through Intramolecular Oxidative Cross-Coupling of Alkenes

Bing Jiang, Meng Zhao, Shu-Sen Li, Yun-He Xu,* Teck-Peng Loh*

Angew.Chem. Int. Ed. 2018, 57, 5555 –5559.

9)     Catalytically Asymmetric Synthesis of 1,3-Bis(silyl)propenes via Copper-Catalyzed Double Proto-Silylations of Polar Enynes.

Fei-Fan Meng, Jia-Hao Xie, Yun-He Xu,* Teck-Peng Loh

ACS Catal. 2018, 8, 5306-5312.

10)   Copper-Catalyzed Stereo- and Enantioselective 1,4-Protosilylation of alpha,beta-Unsaturated Ketimines To Synthesize Functionalized Allylsilanes  

Bing-Chao Da, Qiu-Ju Liang, Yun-Cheng Luo, Tanveer Ahmad, Yun-He Xu,* Teck-Peng Loh

ACS Catal. 2018, 8, 6239-6245.

11)   Palladium-catalyzed silaborative carbocyclization of 1,6-diynes

Qian Zhang, Qiu-Ju Liang, Jian-Lin Xu, Yun-He Xu,* Teck-Peng Loh*

Chem. Commun. 2018, 54, 2357-2360.

12)   Copper-Catalyzed Dehydrogenative Diels-Alder Reaction

Jiang, Bing; Liang, Qiu-Ju; Han, Yu; Zhao, Meng; Xu, Yun-He Xu,* Teck-Peng Loh*

Org. Lett. 2018, 20, 3215-3219.

13)   Multi-catalyst promoted asymmetric relay reactions.

Qiu-Ju Liang, Yun-He Xu, Teck-Peng Loh*

Org. Chem. Front. 2018, 5, 2765-2768.

14)   Palladium-Catalyzed Regioselective Olefination of O‑Acetyl Cyanohydrins.

Liang, Qiu-Ju; Jiang, Bing; Yun-He Xu,* Teck-Peng Loh*

J. Org. Chem. 2018, 83, 8265-8271.

15)   Palladium-Catalyzed One-Pot Highly Regioselective 6-Endo Cyclization and Alkylation of Enynoates: Synthesis of 2‑Alkanone Pyrones

Ahmad, Tanveer; Qiu, Sheng-Qi; Yun-He Xu,* Teck-Peng Loh*

J. Org. Chem. 2018, 83, 13414-13426.

16)   Copper-Catalyzed Silylperoxidation Reaction of α,β-Unsaturated Ketones, Esters, Amides, and Conjugated Enynes

Yun Lan, Xi-Hao Chang, Pei Fan, Cui-Cui Shan, Zi-Bai Liu, Teck-Peng Loh*, Yun-He Xu,*

ACS Catal. 2017, 7, 7120-7125.

17)   Chelation versus Non-Chelation Control in the Stereoselective Alkenyl sp2 C-H Bond Finctionalization Reaction

Qiu-Ju Liang, Chao Yang, Fei-Fan Meng, Bing Jiang, Yun-He Xu,* Teck-Peng Loh*

Angew.Chem. Int.Ed. 2017, 56, 5091 –5095.

18)   Palladium-Catalyzed Direct Intramolecular C−N Bond Formation: Access to Multisubstituted Dihydropyrroles

Bing Jiang, Fei-Fan Meng, Qiu-Ju Liang, Yun-He Xu,* Teck-Peng Loh*

Org. Lett. 2017, 19, 914-917.

19)   Direct coupling of sp3 carbon of alkanes with α,β-unsaturated carbonyl compounds using a copper/hydroperoxide system

    Yun Lan, Chao Yang, Yun-He Xu,* Teck-Peng Loh*

    Org. Chem. Front. 2017, 4, 1411-1415.

20)  Copper-catalyzed silylation reactions of propargyl epoxides: easy access to 2,3-allenols and stereodefined alkenes

    Xi-Hao Chang, Zheng-Li Liu, Yun-Cheng Luo, Chao Yang, Xiao-Wei Liu, Bing-Chao Da, Jie-Jun Li, Tanveer Ahmad, Teck-Peng Loh*, Yun-He Xu*

    Chem. Commun. 2017, 57, 9344-9347.

21)   Palladium-catalyzed Silylation reaction between benzylic halides and silylboronate

    Zhi-Dao Huang, Ran Ding, Peng Wang,* Yun-He Xu,* Teck-Peng Loh

    Chem. Commun. 2016, 52, 5609-5612.

22)   Palladium-catalyzed cross-coupling of enamides with sterically hindered alpha-bromocarbonyls

    Ran Ding, Zhi-Dao Huang, Zheng-Li Liu, Yun-He Xu,* Teck-Peng Loh*

    Chem. Commun. 2016, 52, 5617-5620.

23)   Pd-Catalyzed Intramolecular C-N Bond Cleavage, 1,4-Migration, sp(3) C-H Activation, and Heck Reaction: Four Controllable Diverse Pathways Depending on the Judicious Choice of the Base and Ligand

   Min Wang, Xiang Zhang, Yu-Xuan Zhuang, Yun-He Xu,* Teck-Peng Loh*

   J. Am. Chem. Soc. 2015, 137, 1341-1347.

24)   Stereo- and Chemoselective Cross-Coupling between Two Electron-Deficient Acrylates: An Efficient Route to (Z, E)-Muconate Derivatives

   Xu-Hong Hu, Jian Zhang, Xiao-Fei Yang, Yun-He Xu,* Teck-Peng Loh*

   J. Am. Chem. Soc. 2015, 137, 3169-3172.

25)   Synthesis of Highly Substituted Racemic and Enantioenriched Allenylsilanes via Copper-Catalyzed Hydrosilylation of (Z)‑2-Alken-4-ynoates with Silylboronate

Min Wang, Zheng-Li Liu, Xiang Zhang, Pan-Pan Tian, Yun-He Xu,* Teck-Peng Loh*

   J. Am. Chem. Soc. 2015, 137, 14830–14833.

26)   Copper-Catalyzed Enantioselective Conjugate Addition of Grignard Reagents to Methyl 4,4,4-Trifluorocrotonate: Synthesis of Enantioenriched Trifluoromethylated Compounds

   Li-Ying Zhang, Jia-Hui Zhou, Yun-He Xu,* Teck-Peng Loh*

   Chem. Asian. J. 2015, 10, 844-848.

27)   Palladium-Catalyzed Difunctionalization of Internal Alkynes via Highly Regioselective 6-Endo Cyclization and Alkenylation of Enynoates: Synthesis of Multisubstituted Pyrones

   Pan-Pan Tian, Sai-Hu Cai, Qiu-Ju Liang, Xing-Yi Zhou, Yun-He Xu,* Teck-Peng Loh*

Org. Lett. 2015, 17, 1636-1639.

28)   Palladium-Catalyzed Intermolecular Oxylation of Vinylacetates with Retention of an Alkenyl Moiety

Sheng-Qi Qiu, Yun-He Xu,* Teck-Peng Loh*

   Org. Lett. 2015, 17, 3462-3465.

29)   B(C6F5)3: A New Class of Strong and Bulky Lewis Acid forExo-Selective Intermolecular Diels–Alder Reactions of Unreactive Acyclic Dienes with α,β-Enals

   Jia-Hui Zhou, Bing Jiang, Fei-Fan Meng, Yun-He Xu,* Teck-Peng Loh*

   Org. Lett. 2015, 17, 4432-4435.

30)   Highly Enantioselective and Anti-Diastereoselective Catalytic Intermolecular Glyoxylate–Ene Reactions: Effect of the Geometrical Isomers of Alkenes

   Xiang Zhang, Min Wang, Ran Ding, Yun-He Xu,* Teck-Peng Loh*

Org. Lett. 2015, 17, 2736-2739.

31)   Synthesis of multi-substituted pyrroles using enamides and alkynes catalyzed by Pd(OAc)(2) with molecular oxygen as an oxidant

Yun-He Xu,* Tao He, Qiu-Chi Zhang, Teck-Peng Loh*

Chem. Commun. 2014, 50, 2784-2786.

32)   Synthesis of multi-substituted vinylsilanes via copper(I)-catalyzed hydrosilylation reactions of allenes and propiolate derivatives with silylboronates

Yun-He Xu,* Liu-Hai Wu, Jun Wang, Teck-Peng Loh*

Chem. Commun. 2014, 50, 7195-7197.

 Palladium-Catalyzed Direct Alkynylation of N-Vinylacetamides

Yun-He Xu,* Qiu-Chi Zhang, Tao He, Teck-Peng Loh*

Adv. Synth. Cat. 2014, 356, 1539-1543.

33)   Mild Rh(III)-Catalyzed Direct C-H Bond Arylation of (Hetero)Arenes with Arylsilanes in Aqueous Media

Ming-Zhu Lu, Ping Lu, Yun-He Xu,* Teck-Peng Loh*

Org. Lett. 2014, 16, 2614-2617.

34)   Preparation of highly substituted (β-acylamino)acrylates via iron-catalyzed alkoxycarbonylation of N-vinylacetamides with carbazates

Ran Ding, Qiu-Chi Zhang, Yun-He Xu,* Teck-Peng Loh*

Chem. Commun. 2014, 50, 11661-11664.

35)   Palladium-catalyzed cross-coupling of simple alkenes with acrylates: a direct approach to 1,3-dienes through C-H activation

Zhen-Kang Wen, Yun-He Xu,* Teck-Peng Loh*

Chem. Sci. 2013, 4, 4520-4524. 

36)   Palladium-catalyzed alkenyl C-H bond sulfonylation reaction using organosulfonyl chlorides

Yun-He Xu, Min Wang, Ping Lu, Teck-Peng Loh*

Tetrahedron 2013, 69 4403-4407 (Invited)

37)   Synthesis of Dienyl Ketones via Palladium(II)-Catalyzed Direct Cross-Coupling Reactions between Simple Alkenes and Vinyl Ketones: Application to the Synthesis of Vitamin A1 and Bornelone

Xiang Zhang, Min Wang, Ming-Xin Zhang, Yun-He Xu,* Teck-Peng Loh*

Org. Lett. 2013, 15, 5531-5533.

38)   Palladium-Catalyzed Direct C-H Arylation of Enamides with Simple Arenes

Sreekumar, Pankajashan, Yun-He, Xu, Jun Kee Cheng, Man Ting Low, Teck-Peng Loh*

Angew. Chem. Int. Ed. 2012, 51, 5701-5705.

39)   Palladium-Catalyzed Cross-Coupling of Unactivated Alkenes with Acrylates: Application to the Synthesis of the C13–C21 Fragment of Palmerolide A

Zhen-Kang Wen, Yun-He Xu, Teck-Peng Loh*

Chem. Eur. J. 2012, 18, 13284-13287.

40)   Organoindium Reagents: The Preparation and Application in Organic Synthesis

Zhi-Liang Shen, Shun-Yi Wang, Wew-Keong Chok, Yun-He, Xu, Teck

Peng Loh*

Chem. Rev. 2013, 113, 271-401.