工作单位

中国科学技术大学先进技术研究院/中国科学技术大学生命科学学院

学位/职称

博士/教授

办公室电话

86-551-63606257

Email

qukun@ustc.edu.cn

教育背景

1999-2004    中国科学技术大学化学物理系，获学士学位

2004-2010    美国印第安纳大学化学系，获物理化学博士学位

研究方向

1. 精准医疗，免疫表观遗传基因组学，肿瘤的个性化调控机制

2. 转录因子，非编码RNA 和表观遗传修饰对基因表达的调控作用和机制

3. 生物大数据分析，云计算基础上的生物信息系统分析软件的开发和应用

任职经历

2009-2010    美国希望之城，贝克曼癌症研究中心，生物信息学专家

2010-2016    美国斯坦福大学医学院，生物信息高级研究员，中心主任

2016年至今 中国科学技术大学生命科学学院，教授，博士生导师

主持、参与项目

1. 长链非编码RNA和染色质互作的系统性研究(2017-2019年)

2. T细胞淋巴瘤的表观遗传调控(2018-2021年)

个人获奖

1.     ORISE Fellowship 2007

代表性论著

1. K. Qu*, S. Garamszegi*, F. Wu*, et al, J. Mesirov “Integrative genomic analysis by interoperation of bioinformatics tools in GenomeSpace”, Nature Methods, 2016, Jan 18. doi: 10.1038/nmeth.3732.

2. K. Qu*, L. Zaba*, P. Giresi, et al, H. Chang “Individuality and dynamics of personal regulomes in human T cells”, Cell Systems, 1:51-61, 2015 (Previewed in Cell System)

3. Y. Wan*, K. Qu*, Q. Zhang, R. Flynn, O. Manor, Z. Ouyang, J. Zhang, R. Spitale, M. Snyder, E. Segal and H. Chang “Landscape and variation of RNA secondary structure across the human transcriptome” Nature, 505:706-9, 2014 (Highlighted in Nature News & Views)

4. V. Lopez-Pajares, K. Qu, et al, P. Khavari “A LncRNA-MAF/MAFB Transcription Factor Network Regulates Epidermal Differentiation”, Developmental Cell, 32(6), 693-706, 2015 (Cover Article, Previewed in Developmental Cell)

5. C. Benitez, K. Qu, et al, S. Kim “An Integrated Cell Purification and Genomics Strategy Reveals Multiple Regulators of Pancreas Development”, PLoS Genetics, Oct. 16, 2014

6. J. Quinn, I. Ilik, K. Qu, P. Georgiev, et al., H. Chang “Revealing long noncoding RNA architecture and functions using domain-specific chromatin isolation by RNA purification”, Nature Biotechnology, 32:933-940, 2014

7. P. Batista*, B. Molinie*, J. Wang*, K. Qu, et al., H. Chang “m6A RNA Modification Controls Cell Fate Transition in Mammalian Embryonic Stem Cells”, Cell Stem Cell, 15(6), 707-719, 2014

8. O. Wapinski*, T. Vierbuchen*, K. Qu, et al., H. Chang, and M. Wernig “Hierarchical mechanisms for transcription factor-mediated reprogramming of fibroblasts to neurons” Cell, 155(3), 2013

9. Y. Wan, K. Qu, Z. Ouyang, and H. Chang “Genome-wide mapping of RNA structure using nuclease digestion and high-throughput sequencing” Nature Protocols, 8(5):849-69, 2013

10. N. Rapicavoli, K. Qu, et al., H. Chang “A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics” eLife, July 23, 2013

11. X. Bao, J. Tang, V. Lopaz-Pajares, S. Tao, K. Qu, G. Crabtree, P. Khavari “ACTL6a Enforces the Epidermal Progenitor State by Suppressing SWI/SNF-Dependent Induction of KLF4” Cell Stem Cell, 12(2):193-203, 2013

12. M. Kretz, D. Webster, C. Chu, Z. Siprashvili, A. Zehnder, K. Qu, et al., H. Chang, and P. Khavari “Control of Somatic Tissue Differentiation by the Long Non-Coding RNA TINCR” Nature, 493(7431):231-5, 2013 (Faculty 1000) 

13. R. Flockhart, D. Webster, K. Qu, et al., P. Khavari “BRAFV600E remodels the melanocyte transcriptome and induces BANCR to regulate melanoma cell migration” Genome Research, 22(6):1006-14, 2012 (Highlighted in Nature Reviews Cancer)

14. Y. Wan, K. Qu, Z. Ouyang, et al., E. Segal, H. Chang. “Genome-wide measurement of RNA folding energies” Molecular Cell, 48:1-13, 2012 (Faculty 1000)

15. A. Bhaduri, K. Qu, et al., and P. Khavari. “Rapid Identification of Nonhuman Sequencing in High Throughput Sequencing Data Sets” Bioinformatics, 28(8):1174-5, 2012 (Faculty 1000)

16. N. Gomez-Ospina, A. Chang, K. Qu, A. Oro. “Translocation Affecting Sonic Hedgehog Gene associated with Basal Cell Carcinomas” The New England Journal of Medicine, 366:2233-2234, 2012

17. C. Chu, K. Qu, F. Zhong, S. Artandi, H. Chang. “Genomic maps of lincRNA occupancy reveal principles of RNA-chromatin interactions” Molecular Cell, 44(4), 667-678, 2011 (Cover Article, Highlighted in Nature Reviews Genetics and Nature Methods, Faculty 1000)

18. S. Marro, Z. Pang, N. Yang, M. Tsai, K. Qu, et al., M. Wernig “Direct Lineage Conversion of Terminally Differentiated Hepatocytes to Functional Neurons” Cell Stem Cell, 9(4) 374-382, 2011 (Cover Article, Faculty 1000, and Highlighted in Nature Biotechnology)

19. K. Qu, A. Yesnik, P. Ortoleva. “Alternative splicing regulatory network reconstruction from exon array data” Journal of Theoretical Biology, 263: 471-480, 2010

20. K. Qu, P. Ortoleva, “Understanding stem cell differentiation through self-organization” Journal of Theoretical Biology, 250(4): 606-20, 2008

21. K. Qu, A. Haidar, J. Fan, L. Ensman, K. Tuncay, M. Jolly, P. Ortoleva. “Cancer Onset and Progression: A Genome-Wide, Nonlinear Dynamical Systems Perspective on Onconetworks”. Journal of Theoretical Biology, 246: 234-244, 2007