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孙宝林
文章来源:本站原创
发布时间:2021-12-07 14:14:40
文章作者:本站编辑
导师介绍
姓名 | 孙宝林 | |
工作单位 | 中国科学技术大学先进技术研究院/中国科学技术大学生命科学学院 | |
学位/职称 | 博士/教授 | |
办公室电话 | 0551-63606748 | |
sunb@ustc.edu.cn | ||
教育背景 | 美国Michigan State University微生物学博士 | |
研究方向 | 细菌病原体的耐药与致病性发生的分子机制研究 | |
任职经历 | 2004年至今,中国科学技术大大学生命科学学院,教授。 | |
获得荣誉、奖项 | 1. 王宽诚育才奖(一等奖)(2008) 2. 研究生导师招生先锋奖(2011)
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主持、参与项目 | 1. 结核病靶标研究(2008年科技部重大传染病防治专项) 2. 金黄色葡萄球菌临床菌株III-A CRISPR-Cas 系统的功能与机制研究(2017年面上项目) 3. 金黄色葡萄球菌群体感应信号分子AI-2的受体鉴定及调控致病性的分子机制(2019年面上项目) 4. 金黄色葡萄球菌耐药发生的分子机制研究(2019中科院先导专项) | |
论文、著作 | 1. Jiang Q, Jin Z, Sun B (2018). MgrA negatively regulates biofilm formation and detachment by repressing the expression of psm operons in Staphylococcus aureus. Appl Environ Microbiol 84:e01008-18. 2. Wen W, Liu B, Xue L, Zhu Z, Niu L, Sun B (2018). Autoregulation and virulence control by the toxin-antitoxin system SavRS in Staphylococcus aureus. Infect Immun 86:e00032-18. 3. Guan J, Wang W, Sun B (2017). Chromosomal targeting by the type III-A CRISPR-Cas system can reshape genomes in Staphylococcus aureus. mSphere 2:e00403-17. 4. Zhao C, Shu X, Sun B (2017). Construction of a gene knockdown system based on catalytically inactive ("dead") Cas9 (dCas9) in Staphylococcus aureus. Appl Environ Microbiol 83:e00291-17. 5. Liu X, Zhang S, Sun B (2016). SpoVG regulates cell wall metabolism and oxacillin resistance in methicillin-resistant Staphylococcus aureus strain N315. Antimicrob Agents Chemother 60:3455–3461. 6. Zhang S, Ma R, Liu X, Zhang X, Sun B (2015). Modulation of ccrAB expression and SCCmec excision by an inverted repeat element and SarS in methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 59:6223-6232. 7. Chen C, Zhang X, Shang F, Sun H, Sun B, Xue T (2015). The Staphylococcus aureus protein-coding gene gdpS modulates sarS expression via mRNA-mRNA interaction. Infect Immun 83:3302-3310. 8. Hu J, Zhang X, Liu X, Chen C, Sun B (2015). Mechanism of reduced vancomycin susceptibility conferred by walK mutation in community-acquired methicillin-resistant Staphylococcus aureus strain MW2. Antimicrob Agents Chemother 59:1352-1355. 9. Xue T, You Y, Hong D, Sun H, Sun B (2011). The Staphylococcus aureus KdpDE two-component system couples extracellular K+ sensing and Agr signaling to infection programming. Infect Immun 79:2154-2167. 10. Zhao L, Xue T, Shang F, Sun H, Sun B (2010). Staphylococcus aureus AI-2 quorum sensing associates with the KdpDE two-component system to regulate capsular polysaccharide synthesis and virulence. Infect Immun 78:3506-3515. 11. Tao L, Wu X, Sun B (2010). Alternative sigma factor σH modulates prophage integration and excision in Staphylococcus aureus. PLoS Pathog 6:e1000888. 12. Shang F, Xue T, Sun H, Xing L, Zhang S, Yang Z, Zhang L, Sun B (2009). The Staphylococcus aureus GGDEF domain-containing protein, GdpS, influences protein A gene expression in a cyclic diguanylic acid-independent manner. Infect Immun 77:2849-2856. |