职称/职务

教授

出生年月

1979.11

最高学历

博士

固定电话

0551-63601736

工作单位

（至院、系、所）

 生命科学学院

联系地址

科大西校区科技楼917

邮箱

wxiong@ustc.edu.cn

教育背景

1997/09 – 2001/06，北京大学，生命科学学院，环境生物与生态，学士

2001/09 – 2006/06，北京大学，生命科学学院，神经生物学，博士

研究方向

脑衰老与神经退行性疾病的发生发展机制；

新型质谱技术研发及其在神经科学中的应用；

感知觉的中枢神经环路和调控机制；

离子通道调控机制。

任职经历

2006/10 - 2011/10，National Institutes of Health，Postdoc

2011/10 – 2013/03，National Institutes of Health，Research Fellow

2013/03 – 至今，中国科学技术大学，生命科学与医学部，教授

2019/11-至今，合肥综合性国家科学中心人工智能研究院，副院长

2020/01-至今，中国科学技术大学生命科学学院，副院长

主持、参与

项目

1. 国家自然科学基金重大研究计划重点支持项目，91849206，脑衰老及退行性病变的多尺度全脑胆固醇图谱研究，2019/01-2022/12，主持

2. 中国科学院战略性先导科技专项（B类）“衰老的生物学基础和干预策略”， XDB39000000，衰老研究的新技术与新方法，2020/01-2024/12，主持

3. 科技部十三五国家重点研发计划干细胞及转化研究专项，神经系统多能干细胞谱系分化与命运决定机制研究，2020YFA0112200，2020/09-2025/08，参与

荣誉、奖项

科技部“中青年科技创新领军人才”、科技创新领军人才、中科院优秀导师、中国科学技术大学杰出研究校长奖、唐立新优秀学者奖

科研成果

（论文、著作、

专利等）

1. Hongying Zhu#, Qianqian Li#, Tiepeng Liao#, Xiang Yin, Qi Chen, Ziyi Wang, Meifang Dai, Lin Yi, Siyuan Ge, Chenjian Miao, Wenping Zeng, Lili Qu, Zhenyu Ju, Guangming Huang, Chunlei Cang* & Wei Xiong*. Metabolomic profiling of single enlarged lysosomes. Nature Methods, 18(7):788-798 (2021).

2. Yujun Guo#, Guichang Zou#, Keke Qi, Jin Jin, Lei Yao, Yang Pan, Wei Xiong*. Simvastatin impairs hippocampal synaptic plasticity and cognitive function in mice. Molecular Brain, 14(1): 41 doi: 10.1186/s13041-021-00758-x. (2021)

3. Jin Ye#, Guichang Zou#, Ruichi Zhu, Chao Kong, Chenjian Miao, Mingjie Zhang, Jianchao Li*, Wei Xiong*, and Chao Wang*. Structural basis of GABARAP-mediated GABAA receptor trafficking and functions on GABAergic synaptic transmission. Nature Communications, 12(1):297. doi: 10.1038/s41467-020-20624-z. (2021)

4. Lei Yao , Chengyuan Liu, Ning Wang, Feng Du, Sijia Fan, Yujun Guo, Li Zhang, Yang Pan, Wei Xiong*. Cholesterol regulates cannabinoid analgesia through glycine receptors. Neuropharmacology, 177: 108242. doi: 10.1016/j.neuropharm.2020.108242. (2020)

5. Lei Yao, Marta Wells, Xiongwu Wu, Yan Xu, Li Zhang*, Wei Xiong*. Membrane cholesterol dependence of cannabinoid modulation of glycine receptor. FASEB J, 34: 10920-10930 (2020)

6. Guichang Zou^#, Xin Zuo^#, Kai Chen, Yushu Ge, Xiaoqun Wang, Guangwei Xu, Huan Wang, Chenjian Miao, Zhenyu Xu, Shuangshuang Tian, Zhen Wang, Yifeng Zhou, Wei Wei, Guangming Huang, Dan Liu and Wei Xiong*. Cannabinoids Rescue Cocaine-Induced Seizures by Restoring Brain Glycine Receptor Dysfunction. Cell Reports, 30(12): 4209-4219 (2020)

7. Guichang Zou, Jing Xia, Qianqian Han, Dan Liu, and Wei Xiong*. The synthetic cannabinoid dehydroxylcannabidiol restores the function of a major GABA_A receptor isoform in a cell model of hyperekplexia. Journal of Biological Chemistry. 295: 138-145 (2020)

8. Xiaoqun Wang^#; Yiwen Hou^#; Zhuanghao Hou; Wei Xiong*; Guangming Huang*. Mass Spectrometry Imaging of Brain Cholesterol and Metabolites with Trifluoroacetic Acid-Enhanced Desorption Electrospray Ionization, Analytical Chemistry, 91(4): 2719~2726 (2019)

9. Chengyuan Liu, Keke Qi, Lei Yao, Ying Xiong, Xuan Zhang , Jianye Zang, Changlin Tian, Minggao Xu, Jiuzhong Yang , Zhenkun Lin , Yongmei Lv, Wei Xiong*, and Yang Pan*. Imaging of Polar and Nonpolar Species Using Compact Desorption Electrospray Ionization/Postphotoionization Mass Spectrometry. Analytical Chemistry, 91(10): 6616-6623 (2019)

10. Guichang Zou, Qi Chen, Kai Chen, Xin Zuo, Yushu Ge, Yiwen Hou, Tao Pan, Huilin Pan, Dan Liu, Li Zhang and Wei Xiong*. Human Hyperekplexic Mutations in Glycine Receptors Disinhibit the Brainstem by Hijacking GABAA Receptors. iScience, 19: 634-646 (2019)

11. Hongying Zhu^#; Ning Wang^#; Lei Yao; Qi Chen; Ran Zhang; Junchao Qian; Yiwen Hou; Weiwei Guo; Sijia Fan; Siling Liu; Qiaoyun Zhao; Feng Du; Xin Zuo; Yujun Guo; Yan Xu; Jiali Li; Tian Xue; Kai Zhong; Xiaoyuan Song; Guangming Huang*; Wei Xiong*. Moderate UV exposure enhances learning and memory by promoting a novel glutamate biosynthetic pathway in the brain. Cell, 173, 1716-1727 (2018)

12. Jieping Lu^#*; Sijia Fan^#; Guichang Zou; Yiwen Hou; Tao Pan; Weiwei Guo; Lei Yao; Feng Du; GE Homanics; Dan Liu; Li Zhang; Wei Xiong*. Involvement of glycine receptor α1 subunits in cannabinoid-induced analgesia. Neuropharmacology, 133: 224-232 (2018)

13. Hongying Zhu^#, Guichang Zou^#, Ning Wang^#, Meihui Zhuang, Wei Xiong* & Guangming Huang*. Single-neuron identification of chemical constituents, physiological changes, and metabolism using mass spectrometry. PNAS, 114: 2586-2591 (2017)